Troubleshooting Antibody-Oligo Conjugation
6 Reasons Your Antibody-Oligo Conjugates May be Underperforming The use of antibody-oligonucleotide conjugates has grown rapidly in recent years, driven...
Building Better Bioconjugates: The Importance of Covalent Antibody Conjugation
Antibody conjugates are essential reagents in life science research and biopharmaceutical development, playing a critical role in applications including flow...
QC Strategies for Antibody-Oligo Conjugates: Moving Beyond Degree of Labeling
Antibody-oligonucleotide conjugates are foundational tools within spatial biology, single-cell analysis, and targeted diagnostics. As applications become increasingly sensitive and quantitative,...
Interpreting Antibody Conjugation Efficiency Data: What Actually Matters for Your Assay
Antibody conjugation efficiency is often reduced to a single number, however in reality it is a combination of several chemical...
The Benefits of Site-Specific Antibody Drug Conjugation for High Throughput Discovery
Antibody-drug conjugates (ADCs) have become an important therapeutic modality, particularly in oncology, combining the targeting precision of antibodies with the...
Uniform ADCs and Defined DAR: Foundations for Effective Prototyping
During early ADC prototyping, multiple antibody, linker, and payload combinations must be evaluated to identify the most promising candidates for...
Antibody-Oligonucleotide Conjugation: Methods, Applications, and Trade-offs
A critical design decision in any Antibody-Oligo Conjugate workflow is how the oligonucleotide is chemically attached to the antibody. The...
Oligo-Antibody Ratio: A Critical Parameter in Assay Design
As antibody-oligonucleotide conjugates are increasingly integrated into quantitative, multiplexed, and sequencing-based assay platforms, there is growing recognition that conjugation architecture...
Antibody-Oligo Conjugates: Novel Applications Driving Innovation
In recent years, antibody-oligonucleotide conjugates have emerged as indispensable tools in scientific research, enabling unparalleled capabilities in multiplexing, detection, and...
Webinar: Simple, fast, site-specific antibody labeling with oYo Link®
Watch our short introduction to AlphaThera’s oYo-Link® site-specific antibody conjugation technology and learn how to streamline your assays with these...
Create conjugates for proximity assays & qPCR-enabled proteomics using oYo-Link® Oligo Custom
oYo-Link allows researchers to custom-design their antibody-oligonucleotide conjugates for proximity assays…
Proximity Assays for qPCR-enabled Proteomics: Novel Application of Antibody-Oligo conjugates
Proximity assays combine qPCR and immunoassays to quantify proteins. Learn how to use the power of Antibody-Oligo conjugates to precisely...
How to Maximize the Efficiency of your Click Chemistry Reactions
Click chemistry reactions offer advantages of being fast, selective and easy to perform, and are thus a powerful bioconjugation tool...
Antibody-Oligonucleotide Conjugation Chemistries
In this blog we compare the most common conjugation approach adopted by commercially available technologies, amine conjugation, to AlphaThera’s innovative...
Expand Your Multiplexing Capabilities
In this blog we review the advantages of multiplex assays compared with single-plex assays, the current barriers to preventing scalability...
CITE-seq: Exploiting Antibody-Oligonucleotide Conjugates for Studying Disease at the Cell Level
Single-cell biology is a rapidly growing field of interest providing exciting opportunities in the study of biological mechanisms of disease....
Rapid & effective prototyping is key for antibody-drug conjugate development
How to minimize uncertainty and maximize efficiency of your ADC development experiments Antibody-drug conjugates (ADCs) are a novel type of...
How to easily confirm successful antibody conjugation
Have confidence in your labeling reaction, save time and money Imagine planning a time-consuming experiment with expensive antibodies that should...
Using Site-Specific Antibody Labeling to Improve Antibody Performance & Assay Sensitivity
There are many antibody labeling technologies available on the market that enable quick and easy conjugation to a range of...
Antibody labeling without purification
Save time and wasted materials Prior to labeling an antibody with a fluorescent dye, biotin, oligo or any other label,...
How to overcome poor antibody-oligonucleotide conjugation efficiency
Stop wasting expensive antibody & oligonucleotide The use of antibody-oligonucleotide conjugates is becoming more popular as researchers recognize their benefits...
Immuno-PCR
A powerful method of immunodetection using Antibody-Oligo conjugates Immuno-PCR is a method of immunodetection combining the specificity of an...