oYo-Link® Antibody Labeling Reagents

Simple. Fast. Site-Specific antibody labeling with only 30 seconds hands-on time

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oYo-Link

oYo-Link® Antibody Labeling

Simple, fast, site-Specific antibody labeling with only 30 seconds hands-on time

  • 2 steps, mix & illuminate
  • 30 seconds hands-on time, 2 hours total conjugation time
  • Compatible with all common buffers. 90% labeling efficiency of most antibodies
  • Label as little as 1 µg of antibody per reaction
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Trusted by Scientists Worldwide

oYo-Link® Oligo

Deep-tissue transcriptomics and subcellular imaging at high spatial resolution

Science (2025)

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oYo-Link® Oligo

A method for Boolean analysis of protein interactions at a molecular level

Nature Communications (2022)

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oYo-Link® Oligo

Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution imaging

Cell (2024)

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oYo-Link® Oligo

Efficient DNA fluorescence labeling via base excision trapping

Nature Communications (2022)

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oYo-Link® DBCO

Multiplexed In Situ Imaging of Site-Specific m6A Methylation with Proximity Hybridization Followed by Primer Exchange Amplification

ACS (2024)

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oYo-Link® Oligo

DNA-based AND logic gate as a molecular precision tool: selective recognition of protein pairs in lipid nanodiscs and subsequent binding of gold nanorods

PrePrint: ChemRvix

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oYo-Link® Oligo

Cassini: Streamlined and Scalable Method for in situ profiling of RNA and Protein

PrePrint: BioRvix

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oYo-Link® Epitope Tag

Epitope Tag Conjugation system provides versatility for multiples assay design

The Journal of Immunology (2023)

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oYo-Link® Oligo

High-throughput, multiplexed quantification, and sorting of single EVs at single-molecule level

PrePrint: BioRvix

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oYo-Link® Tetrazine

Peptide sequencing via reverse translation of peptides into DNA

PrePrint: BioRvix

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oYo-Link® Oligo

Fixation Before Dissociation Using a Deep Eutectic Solvent Preserves In Vivo States and Phospho-Signaling in Single-Cell Sequencing

PrePrint: BioRvix

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oYo-Link® Azide

Harnessing Synaptic Vesicle Release and Recycling Mechanism for Molecule Delivery to Neurons

PrePrint: BioRvix

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Our Products

oYo-Link_PE_icon

oYo-Link® SureLight® PE

Rapid, site-specific labeling of compatible antibodies with up to two PE labels. 30 seconds hands-on time, conjugates ready in just 2 hours.

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APC icon

oYo-Link® SureLight® APC

Rapid, site-specific labeling of compatible antibodies with up to two APC labels. 30 seconds hands-on time, conjugates ready in just 2 hours.

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hrp

oYo-Link® HRP

Applicable for direct conjugation of HRP to primary antibodies for ELISA, IHC & western blotting.

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oligo custom

oYo-Link® Oligo Custom

Label as little as 1 µg of Antibody with your custom oligo per reaction. Oligos made by IDT. Supports ssDNA and dsDNA up to 80bp or longer in length.

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View all oYo-Link Products

Columbia Biosciences and AlphaThera partner to develop range of Site-Specific Fluorescent Protein Labeling Reagents

The partnership will provide the life science market with an innovative conjugation chemistry for antibody labeling.

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AlphaThera relocates to accommodate the company’s rapid expansion

AlphaThera have announced their relocation to a new larger laboratory and office space within the Pennovation Works Lab Building at the University of Pennsylvania.

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AlphaThera announces the launch of oYo-Capture™ Magnetic Beads

For the efficient removal of free oYo-Link® post conjugation AlphaThera has announced the launch of oYo-Capture™ Magnetic Beads, providing researchers with an efficient method of removing free oYo-Link® reagents post antibody conjugation to ensure low background in high sensitivity assays. AlphaThera is well known within the life science research community for their oYo-Link® antibody labeling […]

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Our Blog

Simple. Fast. Site-Specific antibody labeling.

Oligonucleotide Labeling

Create conjugates for proximity assays & qPCR-enabled proteomics using oYo-Link® Oligo Custom

oYo-Link allows researchers to custom-design their antibody-oligonucleotide conjugates for proximity assays…

Click Chemistry

How to Maximize the Efficiency of your Click Chemistry Reactions

Click chemistry reactions offer advantages of being fast, selective and easy to perform, and are thus a powerful bioconjugation tool...

Epitope Tags

Expand Your Multiplexing Capabilities

In this blog we review the advantages of multiplex assays compared with single-plex assays, the current barriers to preventing scalability...

Oligonucleotide Labeling

CITE-seq: Exploiting Antibody-Oligonucleotide Conjugates for Studying Disease at the Cell Level

Single-cell biology is a rapidly growing field of interest providing exciting opportunities in the study of biological mechanisms of disease....