oYo-Link® Advantages

Easy & rapid labeling

Reactions require less than 30 seconds hands-on time, 2 hours total.

Covalent, site-specific labeling to the Fc region

No loss in antibody functionality & highly efficient labeling resulting in homogeneous conjugates with 1 to 2 labels per antibody.

Label small amounts

Label as little as 1 µg of antibody at a time and in diluted antibody solutions – 50 µg/mL.

Robust buffer compatibility

No purification steps; 100% sample recovery – no wasting of expensive samples.



1. Hui, J.Z., Tamsen, S., Song, Y., Tsourkas, A. (2015) LASIC: Light activated site-specific conjugation of native IgGs. Bioconjugate Chemistry, 26(8), 1456-1460. DOI: 10.1021/acs.bioconjchem.5b00275


2. Hui, J.Z., Tsourkas, A. (2014) Optimization of photo-active Protein Z for fast and efficient site-specific conjugation of native IgG. Bioconjugate Chemistry, 25(9), 1709-1719. DOI: 10.1021/bc500305v


3. Hui, J.Z., Al Zaki, A., Cheng, Z., McNitt, C.D., Popik, V., Zhang, H., Luning Prak, E.T., Tsourkas, A. (2014) Facile method for the site-specific, covalent attachment of full-length IgG onto nanoparticles. Small, 10(16), 3354-3363. DOI: 10.1002/smll.201303629