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Select from oYo-Link® DM1, DM4, VcMMAE and VcMMAF
oYo-Link® Antibody Drug Conjugation Reagents enable rapid, site-specific labeling of drugs to the heavy-chains of compatible antibodies with up to two labels per antibody. oYo-Link® limits the attachment of the drug to the heavy chains of the antibody and therefore ensures that the drug label does not interfere with antibody binding.
Furthermore, site-specific labeling limits 1-2 drugs to be attached per antibody, providing precise antibody-drug conjugate ratios.
Any free oYo-Link drug will not penetrate into cells, so there is no background cell killing and therefore no requirement for purification post labeling – proceed directly to the cell killing assay.
oYo-Link® Antibody Drug Conjugation Reagents allow for labeling of 100+ antibodies simultaneously for increased high throughput capacity.
Advantages of labeling with oYo-Link® ADC Reagents
- Label 100+ antibodies simultaneously for increased high throughput capacity
- No need for purification post conjugation, proceed directly to the cell killing assay
- Site-specific labeling ensures predictable efficacy and toxicity profiles
- Rapid ADC prototyping: 30 seconds hands on time
- Site-specific labeling guarantees no interference with antibody-binding
- Label as little as 1µg of antibody at a time & work with concentrations as low as 50µg/ml – conduct more experiments with one batch of antibodies and drugs
oYo-Link® ADC Products
oYo-Link® DM4
Site-specifically label your antibody with oYo-Link® DM4 drug for cell killing assays to prototype your ADC candidates.
oYo-Link® VcMMAF
Site-specifically label your antibody with oYo-Link® DM1 drug for cell killing assays to prototype your ADC candidates. Click below to learn more…
oYo-Link® DM1
Site-specifically label your antibody with oYo-Link® DM1 drug for cell killing assays to prototype your ADC candidates.
oYo-Link® VcMMAE
Site-specifically label your antibody with oYo-Link® VcMMAE drug for cell killing assays to prototype your ADC candidates. Click below to learn more…
Two Steps, 30 Seconds Hands-on Time, 100% Sample Recovery
Antibody labeling requires just two steps:
- Mix oYo-Link with your antibody
- Illuminate with non-damaging 365 nm UV light for <2 hours
The entire procedure requires just two steps and less than 30 seconds of hands-on time. Any unused oYo-Link reagent can be saved for later use.
How oYo-Link® Works
oYo-Link reagents consist of low molecular weight (~8 kDa), high-affinity antibody-binding domains that possess a photo-crosslinker within their Fc-binding site. Upon illumination with non-damaging Black-light, oYo-Link forms a covalent bond with the antibody. This procedure is referred to as Light-Activated Site-Specific Conjugation (LASIC). Any label that is attached to oYo-Link will be covalently attached to the desired antibody.
All that is needed to label your antibody is the oYo-Link reagent and our LED photo-crosslinking device to perform the conjugation, or a compatible device.
Watch our webinar to find out more about oYo-Link.
Looking to outsource your antibody-drug conjugation?
AlphaThera also offers affordable, high quality antibody labeling performed by our expert team. Just $75 per conjugate plus the cost of reagents. Speak with our team about your project.
Talk to us about your project