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Successful ADC development is dependent on several factors including the specificity of the antibody, potency of the drug, drug-antibody ratio (known as the DAR), linker stability, and the drug distribution on the antibody. All these factors will affect the safety, efficiency, and delivery of ADCs to target cells. Therefore, the ability to tightly control the labeling process will greatly influence the success of ADC development.
In this eBook we discuss how existing antibody labeling methods create a barrier for ADC development:
The high-throughput capability is limited
Uncertainties arise from non-uniform antibody-drug conjugates.
We also discuss the solution to overcome these barriers using site-specific conjugation that yield homogenous ADCs for rapid prototyping.
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